Andrographolide

Andrographolide yog cov khoom lag luam botanical muab rho tawm los ntawm cov tshuaj ntsuab uas tshwm sim hauv Suav teb.Cov tshuaj ntsuab muaj keeb kwm dav siv hauv TCM rau kev kho mob ntawm cov kab mob ua pa sab saud thiab lwm yam kab mob sib kis.Andrographis paniculata tau qhia thiab cog qoob loo hauv Guangdong thiab yav qab teb Fujian hauv 50s.Nws yog siv los kho ntau yam kab mob sib kis thiab nab tom.Nyob rau hauv xyoo tas los no, kev cog qoob loo, tshuaj muaj pes tsawg leeg, tshuaj kho mob thiab kev kho mob ntawm Andrographis paniculata tau kawm hauv Suav teb.Andrographis paniculata yog ib hom tshuaj suav tshuaj uas niaj hnub siv, uas muaj cov teebmeem ntawm kev tshem tawm cov cua sov thiab cov tshuaj lom, ua kom cov ntshav txias thiab detumescence.Clinically, nws yog tsuas yog siv rau kev kho mob ntawm cov kab mob ua pa, mob bacillary dysentery, gastroenteritis, txias, kub taub hau thiab kub siab.Nrog rau kev siv tshuaj tua kab mob ntau ntxiv thiab cov tshuaj tsis zoo, lub suab ntawm kev tsim cov tshuaj suav tshuaj suav nrog cov tshuaj tua kab mob zoo zuj zus tuaj.Andrographis paniculata, raws li ib txwm suav tshuaj nrog tshuaj tua kab mob, tau them nyiaj ntau dua los ntawm kev lag luam kws tshuaj.

Andrographis paniculata cog extract yog paub tias muaj ntau yam kev ua haujlwm tshuaj.Andrographolide, cov ntsiab lus tseem ceeb ntawm cov extract yog cuam tshuam rau nws cov tshuaj pharmacological.Peb tau kawm txog cov txheej txheem ntawm tes thiab lub hom phiaj hloov kho los ntawm kev kho andrographolide hauv tib neeg mob qog noj ntshav thiab lub cev tiv thaiv kab mob.Kev kho mob Andrographolide inhibited lub hauv vitro proliferation ntawm cov qog cell kab sib txawv, sawv cev rau ntau hom qog noj ntshav.Cov tshuaj tiv thaiv kev ua haujlwm ncaj qha rau cov qog nqaij hlav cancer los ntawm lub voj voog ntawm tes ntawm G0 / G1 theem los ntawm induction ntawm cell-cycle inhibitory protein p27 thiab txo qis kev qhia ntawm cyclin-dependent kinase 4 (CDK4).Immunostimulatory kev ua ntawm andrographolide yog pov thawj los ntawm kev loj hlob ntawm lymphocytes thiab zus tau tej cov interleukin-2.Andrographolide kuj tau txhim kho cov qog necrosis factor-alpha ntau lawm thiab CD marker qhia, uas ua rau muaj zog cytotoxic kev ua ntawm lymphocytes tiv thaiv cov qog nqaij hlav cancer, uas yuav pab tau rau nws indirect anticancer kev ua.Cov kev ua hauv vivo anticancer ntawm cov compound yog ntxiv rau kev tiv thaiv B16F0 melanoma syngenic thiab HT-29 xenograft qauv.Cov txiaj ntsig no qhia tau hais tias andrographolide yog ib qho kev nthuav tshuaj pharmacophore nrog cov tshuaj tiv thaiv kab mob thiab kev ua haujlwm ntawm immunomodulatory thiab yog li muaj peev xwm tsim los ua tus neeg saib xyuas mob qog noj ntshav.